< PreviousCLEANING AND MAINTENANCE 30 Pharma Business International www.pbiforum.netPharma Business International 31 www.pbiforum.net CLEANING AND MAINTENANCE © stock.adobe.com/ auremar example, Electrical Panel Thermography can be used to identify even the most imperceptible flaws in a piece of manufacturing equipment. By measuring the temperature of a piece of machinery or individual component, thermal imaging devices can catch minor electrical faults before they cause serious damage, which ultimately means less downtime is needed for maintenance. Companies can also carry out spectrographic oil analyses to keep their machines running smoothly. The oil used to lubricate manufacturing machinery needs to be uncontaminated in order to do its job properly, but the only sure-fire way to guarantee this is to use an ICP (inductively coupled plasma mass) spectrometer to identify and weed out unwanted particle compositions. Conducting oil sample analysis can help to prolong the lifespan of machinery and should be carried out on a routine basis. Acoustic vibration monitoring technology, which costs relatively little, can also be employed to check the condition of mechanical parts. Industrial rotors, for example, will emit higher- frequency sounds if they sustain any damage. By using an Acoustic Emission (AE) sensor to detect early signs of friction, companies can address problems before they cause production to grind to a halt. It is vital to keep machinery as clean as possible – especially in an environment where pharmaceuticals are being produced. In order to remove potentially hazardous blockages, manufacturers are investing in UHP pipe-cleaning technologies which employ water pressure to achieve a more powerful clean. The latest products on the market are able to clean lengths of piping over 1 km long, and because many of them feature sophisticated rotary heads that increase water propulsion, they are also able to clean around bends. Cleaning of machinery can also be an area where accidents (some fatal) can happen, however. When dealing with particularly dangerous or heavy machinery, companies should institute a permit-to-work system to ensure that, a) only highly trained operatives have access to the machinery, and b) that no individual is required to use a piece of machinery for longer than is necessary. It is similarly vital that machines are positioned in unconfined spaces on the factory floor. This not only reduces the risk of getting trapped in the moving parts of machines, but it also lessens the chances of an operative inhaling the dust that is an inevitable by-product of many pharma manufacturing processes. Dust inhalation and other issues such as eye and skin irritation can also be prevented if companies provision their staff with the correct safety equipment and take the trouble to install high- quality exhaust ventilation systems. Clean air is, of course, important, but is also by now a factor that every manufacturer should be wholly aware of. That said, given the nature of dust particulates and how difficult it is to detect them, many companies fail to maintain their air filtration systems as stringently as they should. It's tempting, perhaps even cost- efficient, to focus on inspecting and repairing machinery directly related to profit-making, i.e. the manufacturing line, but this attitude is self-defeating in the long run. All machinery breaks eventually and catching it before it goes bad will save a company more in terms of money and time in the long run, hence the importance of spot inspections. World ADC Asia 25 - 27 June Incheon, South Korea Back by popular demand after a short break, the 3rd World ADC Asia is bringing together pioneers and key opinion leaders across mega-pharma and biotechnology focusing on China, Japan, Taiwan, South Korea and Singapore. They’ll be sharing their most pressing challenges, novel payloads, conjugation, and linker innovations to inform ADC development and improve targeting accuracy. 12th Annual Tumor Models Boston Summit 23 - 24 July Boston, USA The 12th Annual Tumor Models Boston Summit is the only industry-led meeting uniting 200+ industry experts from pharma, biotech, academic KOLs and preclinical CROs to delve into the latest case studies in leveraging PDX models, genetically engineered mouse models, advanced 3D in vitro models and more. Join industry leaders developing teams in preclinical, translational, pharmacology, discovery, pharmacodynamics, toxicity and biology to optimize and implement more translatable oncology models. Pharma EVENTS © stock.adobe.com/Koonsiri © stock.adobe.com/Alena 32 Pharma Business International www.pbiforum.net CPHI South East Asia 10 - 12 July Bangkok, Thailand A leading pharmaceutical solutions event, where a trade show on products, technologies, innovations, seminars on raw materials, pharmaceutical ingredients, and much more, is to happen to promote the pharmaceutical industry in South East Asia. 3rd Cell Therapy Analytical Development Summit Europe 3 - 5 September London, UK Faced with many regulatory bottlenecks, the Targeted Radiopharmaceuticals Summit US 30 July - 1 August San Diego, USA Join the 3rd Annual Targeted Radiopharmaceutical Summit US, the industry’s number one radio-conjugate dedicated event of the year. Whether it’s discussing approaches for novel targets to decrease competition, radioisotope supply so your trial doesn’t get held up or combination or personalized therapies to know the best rationale for combos and maximize the therapeutic window - this is THE forum to learn from industry to ensure you maintain your competitive advantage from the rest of the crowd as you scope the TRP landscape. ASCO Breakthrough 8 - 10 August Yokohama, Japan The 2024 ASCO Breakthrough meeting will bring together the worldwide oncology community for three days of interactive, high- impact scientific and education sessions. This meeting focuses on how innovations in technology create solutions and challenges in providing optimal care to patients and driving the most impactful research. European cell therapy community must unite and confront these challenges head-on. The 3rd Cell Therapy Analytical Development Summit Europe is your unmissable opportunity to connect with peers, share pain points and establish analytical standards for smoother interactions with regulatory bodies including the FDA, EMA and MHRA. Join analytical development and quality control experts from industry-leaders like Achilles Therapeutics, Avobis Bio, Bristol Myers Squibb, Johnson & Johnson, GSK, MHRA, to tackle challenges from product characterisation to method validation and release preparation. 15th Annual World Bispecific Summit 3 - 5 September Boston, USA As of 2023, more than 10 bispecific antibodies have been successfully approved by the FDA, and more than 100 are currently in clinical trials, highlighting biopharma’s continued investment within bispecific therapeutics. As we look to the future of bispecific drugs and focus on novel formats and exploring new mechanisms to differentiate from the crowd, the 15th World Bispecific Summit continues to be the industry’s one-stop-shop for all your strategic needs within bi, tri or multi-specifics or even bispecific ADCs or BiTEs. www.pbiforum.net Pharma Business International 33 Women’s Health Therapeutics and Diagnostics Summit 23 - 25 July Boston, USA From endometriosis to bacterial vaginosis, infertility, pre-term birth and menopause, the need for technological advancements and innovative pipeline developments has never been higher for women’s reproductive health. The Women’s Health Therapeutics & Diagnostics Summit is your focused forum to unite with the likes of Ferring Pharmaceuticals, Organon, Hera Biotech, Evvy, Gynica, Freya Bioscience and more sharing case studies and data-driven insights, bringing the latest technological developments to the forefront and overcoming the current translational challenges. © stock.adobe.com/ zevana Pharmaconex 8 - 10 September Cairo, Egypt Pharmaconex is Africa’s pharmaceutical manufacturing hub, connecting the entire supply chain in Egypt, the largest producer of the pharmaceutical market in the MENA region. Pharmaconex offers a comprehensive experience for the pharma community to network and build knowledge around the latest industry trends.FEATURES Packaging Temperature Control Software & IT Systems Materials Handling Marketing Next issue: Deadline - 24th July 2024 REGULARS News Events M&A Round-up Eye On Approvals Visit us at www.pbiforum.net where you’ll find the latest news as it breaks – and why not subscribe to our newsletters so you can have the latest news emailed to your inbox, in between digital issues? @pbiforumwww.pbiforum.netcompany/pbiforumNext >