< PreviousCLEANING AND MAINTENANCE 30 Pharma Business International www.pbiforum.net © stock.adobe.com/auremar 28-31.qxp_Layout 1 10/06/2022 15:03 Page 3Pharma Business International 31 www.pbiforum.net CLEANING AND MAINTENANCE the temperature of a piece of machinery or individual component, thermal imaging devices can catch minor electrical faults before they cause serious damage, which ultimately means less downtime is needed for maintenance. Companies can also carry out spectrographic oil analyses to keep their machines running smoothly. The oil used to lubricate manufacturing machinery needs to be uncontaminated in order to do its job properly, but the only sure-fire way to guarantee this is to use an ICP (inductively coupled plasma mass) spectrometer to identify and weed out unwanted particle compositions. Conducting oil sample analysis can help to prolong the lifespan of machinery and should be carried out on a routine basis. Acoustic vibration monitoring technology, which costs relatively little, can also be employed to check the condition of mechanical parts. Industrial rotors, for example, will emit higher-frequency sounds if they sustain any damage. By using an Acoustic Emission (AE) sensor to detect early signs of friction, companies can address problems before they cause production to grind to a halt. It is vital to keep machinery as clean as possible – especially in an environment where medicine is being produced, especially with material that can build up over time in pipes. In order to remove potentially hazardous blockages, manufacturers are investing in UHP pipe-cleaning technologies which employ water pressure to achieve a more powerful clean. The latest products on the market are able to clean lengths of piping over 1 km long, and because many of them feature sophisticated rotary heads that increase water propulsion, they are also able to clean around bends. Where particularly dangerous, heavy machinery is being used, companies should institute a permit-to-work system to ensure that, a) only highly trained operatives have access to the machinery, and b) that no individual is required to use a piece of machinery for longer than is necessary. It is similarly vital that machines are positioned in unconfined spaces on the factory floor. This not only reduces the risk of getting trapped in the moving parts of a machine, but it also lessens the chances of an operative inhaling the dust that is an inevitable by- product of pill manufacturing and coating processes. Dust inhalation and other issues such as eye and skin irritation can also be prevented if companies provision their staff with the correct safety equipment and take the trouble to install high-quality exhaust ventilation systems. Clean air is, of course, important, but is also by now a factor that every manufacturer should be wholly aware of. That said, given the nature of dust particulates and how difficult it is to detect them, many companies fail to maintain their air filtration systems as stringently as they should. There has always been a human need for clean working conditions but given the difficulties in finding the right staff nowadays and with skills shortages across the entire sector, there are even more reasons to take the matter seriously. Removing reasons for employees to consider leaving is a quick and comparatively inexpensive method of avoiding recurring recruitment costs. It’s tempting, perhaps even cost- efficient, to focus on inspecting and repairing machinery directly related to profit-making, i.e. the manufacturing line, but this attitude is self-defeating in the long run. All machinery breaks eventually and catching it before it goes bad will save a company more in terms of money and time in the long run, hence the importance of spot inspections. 28-31.qxp_Layout 1 10/06/2022 15:03 Page 4Gene Therapy for Neurological Disorders Europe 11 - 13 July Paris, France As programs advance globally, the 3rd Annual Gene Therapy for Neurological Disorders Europe meeting is the field’s definitive forum to showcase the European landscape’s progress and specific regulatory challenges. Gene therapy developers from all of the world, including Europe’s brightest minds in CNS gene therapy, will unite in Paris to share their research progress and host an industry- dedicated discussion. BCMA Targeted Therapies Summit 12 - 14 July Boston, USA The BCMA Targeted Therapies Summit returns for its second year, as the industry’s definitive conference dedicated to: exploring and differentiating the next-generation drug modalities targeting BCMA, including bispecific antibody constructs, antibody–drug conjugates, and chimeric antigen receptor (CAR)-modified T-cell therapy; rationalising combination approaches and cracking the sequencing Pharma EVENTS © stock.adobe.com/Syda Productions 32 Pharma Business International www.pbiforum.net Epigenetic-Targeted Drug Discovery & Development Summit 26 - 28 July Online The 3rd Annual Epigenetic-Targeted Drug conundrum to overcome resistance mechanisms; sharing toxicology and safety data to optimise drug potency and balancing dose-response relationships, particularly when it comes to combination strategies; investigating multiple myeloma biology and quantifying BCMA using optimised preclinical models and assays to accelerate translation of preclinical assets into the clinic. Clinical Operations in Oncology Trials East Coast 19 - 20 July Newton, USA Clinical Operations in Oncology Trials East will be returning as a physical event in Boston in July 2022. The event will offer clinical trial professionals from big and small pharma and biotechs in the oncology space an opportunity to uncover new technologies and processes to optimise their clinical and outsourcing operations. The programme will take a holistic approach to the latest challenges and innovations in oncology operations such as end-user-CMO relationship during COVID-19, the evolvement of virtual trials and DTP in oncology trials along with regulatory updates in clinical trials. The conference will also be the platform for innovative case studies and break out discussions to connect and enhance your knowledge in the oncology space. © stock.adobe.com/Gennady Danilkin Aseptic Processing Conference 19 - 20 September London, UK The aseptic processing industry has seen consistent growth in recent years, with advances in innovative therapeutics, the introduction of novel techniques and personnel protocols, the integration of robotics and automation in filling lines, and rise of rapid microbiological methods being just a few of the factors behind this. This conference will explore the novel methods and technologies pushing innovation in the field. Attend to discuss the revisions and the impact of Annex 1 on aseptic manufacturing, explore the applications of rapid micro methods in the manufacture of sterile products, discover a Risk Based Approach to Cleaning and Disinfection, delve into case studies of competence in global aseptic manufacturing, uncover the journey of Isolation Technology in a large Biotech pharmaceutical plant. 32-33.qxp_Layout 1 10/06/2022 15:04 Page 1Discovery & Development Summit is a devoted industry-specific forum exclusively focused on showcasing the latest research and pre-clinical and translational development of small-molecule, and other epigenetic modulators of gene expression, whilst providing pivotal insights to kickstart the next generation of clinically defining therapeutics and help overcome early-stage clinical trial challenges. Attendees can expect to hear the latest discovery, preclinical and translational advancements in therapeutic interventions targeting all areas of epigenetic machinery including DNA methylation, histone post-translational modifications, chromatin remodeling, and non-coding RNAs (ncRNAs) for cancer therapies. Cell Therapy Analytical Development Summit Europe 23 - 25 August London, UK There are now a vast number of biopharma companies that are engaged in the discovery and development of cell therapies, but significant advances in analytical and bioanalytical technologies are required to support R&D, pre-clinical and clinical development of these modalities. Uniting leading analytical, QC, CMC, regulatory and process development experts, the Cell Therapy Analytical Development Summit Europe is the industry’s definitive meeting focused on tackling the greatest analytical development challenges in the context of cell therapy drug development. www.pbiforum.net Pharma Business International 33 © stock.adobe.com/THANANIT New Modalities in Pharmacology and Drug Discovery 4 - 5 July London, UK This joint meeting from the British Pharmacological Society and the European Laboratory Research & Innovation Group (ELRIG UK), will take place in person at the Francis Crick Institute. The conference will explore new pharmacological modalities of differing mechanisms, shapes and sizes and how these are being translated to create patient benefit. As a joint meeting of drug discovery and pharmacology experts it will focus on cross learning opportunities. The event will stimulate thoughts on which disease-affected pathways might benefit from emerging therapeutic modalities and how academic and industry research into these modalities reveal deeper pharmacology, thus completing the “bench to bedside and back to bench” cycle of effective drug discovery. World Orphan Drug Congress 2022 11 - 13 July Boston, USA The World Orphan Drug Congress brings together leading pharmaceutical and biotech companies, government and regulatory authorities, patient advocacy groups, payers, investors and solution providers. The conference is a place to meet and brainstorm ways to advance orphan drug development and improve access to life-saving therapies. 32-33.qxp_Layout 1 10/06/2022 15:04 Page 2FEATURES Packaging Temperature Control Software & IT Systems Materials Handling Marketing Next issue: Deadline - 3rd August 2022 REGULARS News Events M&A Round-up Eye On Approvals Visit us at www.pbiforum.net where you’ll find the latest news as it breaks – and why not subscribe to our newsletters so you can have the latest news emailed to your inbox, in between digital issues? @pbiforumwww.pbiforum.netcompany/pbiforum 34.qxp_Layout 1 10/06/2022 15:05 Page 1Next >