GSK and the University of Oxford have entered a new research collaboration focused on the potential of cancer prevention through vaccination. The GSK-Oxford Cancer Immuno-Prevention Programme will conduct translational research, exploring precancer biology to generate key insights on how cancer develops in humans that could inform new approaches to cancer vaccination. GSK will invest up to £50 million over a minimum of three years to support this early research.
Evidence shows that most cancers take years or even decades to develop from normal cells to precancerous cells (or precancer) to cancer. Oxford University has world-leading expertise in the study of precancer biology including the identification and sequencing of neoantigens, or tumour-specific proteins that prompt the immune system to recognise cancer. This unique focus could help target the vulnerabilities of precancerous cells through an active intervention like a vaccine or targeted medicine to prevent them from progressing to cancer.
Tony Wood, Chief Scientific Officer, GSK, said: “We’re pleased to further strengthen our relationship with Oxford University and to combine the deep knowledge of Oxford and GSK scientists. By exploring precancer biology and building on GSK’s expertise in the science of the immune system, we aim to generate key insights for people at risk of developing cancer.”
Professor Irene Tracey, Vice-Chancellor of the University of Oxford, said: “This partnership represents a step forward in cancer research. By working with GSK to unite experts in clinical trials, immuno-oncology, vaccinology and precancer research from across the University of Oxford, we aim to unlock the potential of cancer vaccines and bring hope to patients worldwide.”
Building on GSK’s ongoing relationship with Oxford, this collaboration will continue to combine GSK’s expertise in the science of the immune system and global development capability with Oxford’s cutting-edge research, clinical capabilities and world-leading scientists.
In 2021, GSK and Oxford established the Institute of Molecular and Computational Medicine. The Institute, based at the University of Oxford, has demonstrated progress at improving the success and speed of research and development of new medicines, specifically in the field of neurodegeneration, building on insights from human genetics and using advanced technologies such as functional genomics and machine learning.
